EmbryoGlue is a specialised hyaluronic acid culture medium used in the laboratory immediately before embryos are transferred to the uterus.
This method is designed to support implantation by helping the embryos to attach to the uterine lining.
It is a culture medium enriched with hyaluronic acid (HA); a naturally occurring substance in the uterus that plays a key role during implantation. This medium is used in the final stage of IVF to improve the connection between the embryo and the uterine lining.
Hyaluronan levels naturally rise in the uterus at the time of implantation, helping the embryo and uterine lining interact effectively.
By mimicking this natural process, the special medium can help create the optimal conditions for implantation.
EmbryoGlue is not a literal glue but works like one by increasing the likelihood of the embryo attaching to the uterine lining. It contains a high concentration of hyaluronan and recombinant human albumin, which:
If we use this special medium for your treatment, we replace the standard culture medium during embryo transfer. The embryo is placed in EmbryoGlue for a short time before transfer.
The transfer procedure itself stays the same. However, the hyaluronate-enriched medium mimics the womb’s environment potentially improving the chances of implantation.
EmbryoGlue may be especially helpful for:
The use of EmbryoGlue and similar hyaluronic acid-enriched culture media is a relatively new method in fertility treatment.
Although there is no conclusive scientific evidence of efficacy yet, recent studies show promising results:
We are committed to offering treatments backed by evidence and designed to give you the best possible outcome.
Due to the relatively limited but growing body of evidence, EmbryoGlue remains an optional treatment.
In 2023, the HFEA classified it as an ‘add-on’ with a yellow rating, meaning there is some evidence suggesting it may be effective, but more research is needed. However, as no adverse effects have been reported, we offer it as an option for patients for whom it may be relevant.
At Diers, we plan every treatment individually. EmbryoGlue may not be the right option for everyone. So, we only recommend it when we believe it could improve the chances of pregnancy based on your specific circumstances.
EmbryoGlue is used in the laboratory before egg transfer. Shortly before egg transfer, the embryo is placed in this special culture fluid for about 10 minutes and then transferred to the uterus.
EmbryoGlue can increase the chances of embryo attachment to the lining of the uterus. It contains hyaluronic acid, which creates a favourable environment and can improve the embryo’s ability to implant (attach).
EmbryoGlue can improve the conditions for implantation, but it is not a guarantee of pregnancy. The success of IVF treatment depends on many factors such as the quality of the embryo, the condition of the uterus and the woman’s general health. EmbryoGlue is just one of several methods we can use to optimise your chances.
Hyaluronic acid is a naturally occurring substance in the body that helps cells bind to each other and keeps tissue moist and supple. Hyaluronic acid is also used in skincare products to moisturise the skin. In EmbryoGlue, hyaluronic acid mimics the natural environment of the uterus and can make it easier for the embryo to attach.
No, we do not routinely use EmbryoGlue for all our patients. Its use depends on individual circumstances and the treatment plan recommended by your fertility specialist. Some patients may not require it, while others may benefit significantly.
Yes, culture media enriched with hyaluronic acid is generally considered safe. It has been extensively researched and is widely used in fertility clinics around the world. There are no known risks or side effects. Studies have shown that it does not increase the risk of miscarriage. It also does not affect the duration of pregnancy or the birth weight of the baby.
You can find the cost of treatment with EmbryoGlue in our current price list.
Yes, the use of EmbryoGlue is optional. Your fertility doctor will explain its potential benefits and help you decide if it’s the right choice for your treatment plan.
Yes, other techniques, such as Endometrial scratching, Assisted Hatching, or optimising hormone levels, may also improve implantation rates. Our fertility specialists will customise a plan based on your needs.
Yes, EmbryoGlue is suitable for use with both fresh and frozen embryo transfers. It supports the embryo implantation regardless of the transfer method.
